Functional results after reconstruction with modular tumor endoprostheses in patients with malignant bone tumors

Introduction: The functional outcome in patients after limb salvage surgery, and in particular reconstructions with modular tumor endoprostheses, has been the subject of many international series, but only a few publications mention the functionality in a Bulgarian patient group.Aim: The aim of the present study was to analyze the functional outcom

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Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification

Plant morphogenesis relies on precise gene expression programs at the proper time and position which is orchestrated by transcription factors (TFs) in intricate regulatory networks in a cell-type specific manner.Here we introduced a comprehensive single-cell transcriptomic atlas of Arabidopsis seedlings.This atlas is the result of meticulous integr

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Human-Centered Design as an Integrating Discipline

What is research today? Good research has to be indexed within appropriate mechanisms to be visible, considered and finally useful.These mechanisms are based on quantitative research methods and codes that are often very academic.Consequently, they impose rigorous constraints on the way results should be obtained and presented.In addition, everythi

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